| The dysbiosis of the gut microbiota is closely related to various diseases, and restoring microbial balance by modulating gut microbiota composition has emerged as a novel therapeutic approach. Fecal microbiota transplantation (FMT), an emerging biotechnology, aims to treat diseases by reconstituting the gut microbiota with a healthy microbiome. However, its mechanisms, long-term efficacy, and potential adverse effects require further investigation, including the impact of dosage and route of administration. Animal models of FMT offer unique advantages in comparing the efficacy of different dosages and transplantation routes, as well as in observing long-term effects, which is helpful for our understanding the technology of FMT. Therefore, this article summarizes the advancements in FMT using mouse, rat, pig, dog, and primate models, providing new insights for the future development of personalized and precision FMT strategies. |
