| Infectious diseases refer to all diseases caused by pathogens that invade the body, which seriously threaten human health and social stability. Anti-infective drugs are essential for the treatment of infectious diseases. In recent years, the resistance of pathogens to anti-infective drugs has gradually increased, and modern medicine has encountered a bottleneck in the treatment of infectious diseases. Mesenchymal stem cells (MSCs), which are pluripotent stem cells of mesodermal origin, have shown great potential in the treatment of infectious diseases, and the mechanisms are closely related to the multidirectional differentiation potential, immunomodulatory function and secretion of antimicrobial substances. MSCs can secrete antimicrobial substances to inhibit the growth and reproduction of pathogens, also can differentiate into different types of cells for tissue repairing. Their immunomodulatory function can not only promote the immune response to clear pathogens, but also inhibit inflammatory storms to reduce the damage to the tissue. The application of MSCs is promising, but there are still many challenges. For example, no clinical application specification, low homing rate and survival rate after injection into the body, may trigger immune rejection and tumor formation. To carry out in-depth basic and clinical research on MSC therapy for infectious diseases, to elucidate its therapeutic mechanism and precisely utilize its therapeutic advantages, to improve the safety and efficacy of MSC therapy through gene editing and other technologies, and to develop more efficient MSC therapeutic protocols, so as to bring a new hope to patients with infectious diseases. |
