| Multimerized nanoantibodies (MN) produced by E. coli have been widely used in medical diagnosis, treatment, foods detection and other aspects of researches. MN can be formed by recombination and fusion of specific multimolecular domains with nanoantibody, which can improve the stability, affinity, anti-hydrolysis ability and prolong the serum half-life, and improve the detection sensitivity. In this review, the types, formation mechanisms, functions and the latest research progress of MN are summarized. This paper reviews the effects of MN on anti-tumor and anti-virus, as well as their ability as "probes" to diagnose diseases, to detect trace pollutants in the foods and in the environment, so as to provide new ideas for the application of MN in the disease treatment, diagnosis, and the R&D of detection reagents. |
