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蛹虫草缓解新型冠状病毒感染研究进展 |
Advances in Alleviating Novel Coronavirus Infection with Cordyceps militaris |
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DOI:doi:10.3969/j.issn.1005-7021.2024.02.011 |
中文关键词: 蛹虫草 SARS-CoV-2 新型冠状病毒感染 虫草素 免疫调节 |
英文关键词: Cordyceps militaris SARS-CoV-2 COVID-19 cordycepin immunoregulation |
基金项目:辽宁省科技厅面上项目(2023-MS-251);辽宁省教育厅重点攻关项目(LJKZZ20220116) |
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中文摘要: |
严重急性呼吸综合征冠状病毒2(SARS-CoV-2)引起的COVID-19在全球范围内大流行,危害了人类健康和公共安全,随着对SARS-CoV-2的结构、功能和致病过程的了解,越来越多的潜在药物被开发。蛹虫草(Cordyceps militaris)是我国传统的药用真菌,具有显著的抗病毒作用,虫草素作为蛹虫草的主要活性成分能够与SARS-CoV-2刺突蛋白、主蛋白酶(Mpro)相结合,抑制病毒RNA依赖的RNA聚合酶(RDRP)活性,阻断SARS-CoV-2在机体内复制。蛹虫草还具有提升机体免疫力、修复受损组织的作用。本文概述虫草素抗SARS-CoV-2的机制和蛹虫草其他相关药理作用,以期为蛹虫草用于新型冠状病毒感染的辅助治疗提供参考。 |
英文摘要: |
COVID-19 caused by SARS-CoV-2 is a global pandemic disease, endangering human health and public safety. With the understanding of the structure, function and pathogenic process of SARS-CoV-2, more and more potential drugs are being developed.Cordyceps militaris is a traditional medicinal fungus that has significant antiviral effects. Cordycepin is the main active component of C.militaris which can combine with SARS-CoV-2 spike protein and main protease (Mpro), inhibit viral RdRp polymerase, and prevent SARS-CoV-2 from replicating in the body. C.militaris also has the function of improving the body′s immunity and repairing damaged tissues. The anti-SARS-CoV-2 mechanism of cordycepin and other related pharmacological functions of C. militaris were summarized. This review will provide reference for the adjuvant therapy of cordycepin for COVID-19. |
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