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| 蛹虫草缓解新型冠状病毒感染研究进展 |
| Advances in Alleviating Novel Coronavirus Infection with Cordyceps militaris |
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| DOI：doi:10.3969/j.issn.1005-7021.2024.02.011 |
| 中文关键词: 蛹虫草 SARS-CoV-2 新型冠状病毒感染 虫草素 免疫调节 |
| 英文关键词: Cordyceps militaris SARS-CoV-2 COVID-19 cordycepin immunoregulation |
| 基金项目:辽宁省科技厅面上项目（2023-MS-251）；辽宁省教育厅重点攻关项目（LJKZZ20220116） |
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| 中文摘要: |
| 严重急性呼吸综合征冠状病毒2（SARS-CoV-2）引起的COVID-19在全球范围内大流行，危害了人类健康和公共安全，随着对SARS-CoV-2的结构、功能和致病过程的了解，越来越多的潜在药物被开发。蛹虫草（Cordyceps militaris）是我国传统的药用真菌，具有显著的抗病毒作用，虫草素作为蛹虫草的主要活性成分能够与SARS-CoV-2刺突蛋白、主蛋白酶（Mpro）相结合，抑制病毒RNA依赖的RNA聚合酶（RDRP）活性，阻断SARS-CoV-2在机体内复制。蛹虫草还具有提升机体免疫力、修复受损组织的作用。本文概述虫草素抗SARS-CoV-2的机制和蛹虫草其他相关药理作用，以期为蛹虫草用于新型冠状病毒感染的辅助治疗提供参考。 |
| 英文摘要: |
| COVID-19 caused by SARS-CoV-2 is a global pandemic disease, endangering human health and public safety. With the understanding of the structure, function and pathogenic process of SARS-CoV-2, more and more potential drugs are being developed.Cordyceps militaris is a traditional medicinal fungus that has significant antiviral effects. Cordycepin is the main active component of C.militaris which can combine with SARS-CoV-2 spike protein and main protease (Mpro), inhibit viral RdRp polymerase, and prevent SARS-CoV-2 from replicating in the body. C.militaris also has the function of improving the body′s immunity and repairing damaged tissues. The anti-SARS-CoV-2 mechanism of cordycepin and other related pharmacological functions of C. militaris were summarized. This review will provide reference for the adjuvant therapy of cordycepin for COVID-19. |
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