| Traumatic brain injury is a disease with high mortality rate, which seriously endangers human life and health. Gut brain axis is the main two-way communication pathway between brain and gastrointestinal system. Recently, the interaction between traumatic brain injury and intestinal flora has been gradually revealed. Intestinal microbial population participates in the regulation of acute pathological injury after traumatic brain injury through intestinal brain axis and plays an important role. This paper reviews the occurrence of traumatic brain injury, its great impact on human health, the meaning of intestinal brain axis and its pathological regulation mechanism in craniocerebral injury. On this basis, this paper discusses and puts forward possible treatments, including fecal microbiota transplantation, probiotics, vagus nerve stimulation, intake of polyphenols and targeted immune regulation strategies, so as to provide new ideas for the clinical treatment of traumatic brain injury. |
