文章摘要
益生菌与宿主疾病关系的研究进展
Advances in Relationship between Probiotics and Host Diseases
  
DOI:doi:10.3969/j.issn.1005-7021.2020.04.014
中文关键词: 肠道菌群  益生菌  失衡  宿主疾病  干预机制
英文关键词: intestinal microbial community (IMC)  probiotic  dysbiosis  host disease  interfering mechanism
基金项目:上海市科技创新行动计划项目(18495800400);上海市农委科技兴农项目(沪农科推字(2017)第4-4号);生鲜肉制品食源性致病菌的“可视化”智能互联快速检测产品研发项目(19391902000)
作者单位
张闻桐 上海理工大学 医疗器械与食品学院上海 200093 
郭亮 上海理工大学 医疗器械与食品学院上海 200093 
李杰 上海理工大学 医疗器械与食品学院上海 200093 
黄志强 上海理工大学 医疗器械与食品学院上海 200093 
闫帅帅 上海理工大学 医疗器械与食品学院上海 200093 
文一 生态环境部 环境规划院北京 100012 
刘箐 上海理工大学 医疗器械与食品学院上海 200093 
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中文摘要:
      人类肠道中含有的多种微生物,称为肠道菌群,它们对宿主的健康起着至关重要的作用。肠道菌群的组成包括细菌、病毒和真核生物,已经被证明与宿主健康有密切的联系,尤其是其中的益生菌。益生菌通过多种途径发挥作用,包括与宿主微生物的相互作用、抵御病原菌的定殖、改善肠道屏障功能、调节免疫功能、产生相关代谢产物,在宿主的代谢、免疫和神经系统中发挥有益作用。综述益生菌的作用机制,讨论了近年来益生菌应用临床研究实例以更好地理解其对疾病风险和健康可持续性的贡献,将为新的治疗干预和疾病预防策略提供参考。
英文摘要:
      In human intestines harbors diverse microbes, called intestinal microbial community (IMC), they play the most important role in the health of their host. The constituents of IMC includes bacteria, viruses, and eucaryotic organisms, they have been proved to have close relation with the host′s health, especially probiotics. Probiotics play their role through many pathways, including the interaction with the host′s microbes, to resist the setting of pathogen, to improve the function of preventive screen of intestines, to regulate the function of immunity, to produce correlated metabolites, they play beneficial role in host′s metabolism, immunity, and nervous system. This paper summarizes the functional mechanism of probiotics, discusses the recent clinical study application cases of probiotics so as to better understand the distribution of probiotics on the risk of diseases and the sustainability of health, and will point out a road for new therapeutic interfering in and diseases prevention tactics.
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