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| 微生物发酵法生产1,3-丙二醇的研究新进展 |
| New progress in microbial fermentation of 1,3-propanediol |
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| DOI：doi:10.3969/j.issn.1005-7021.2016.06.001 |
| 中文关键词: 1,3-丙二醇 微生物发酵 代谢途径 下游分离工艺 |
| 英文关键词: 1,3-propanediol microbial fermentation metabolic pathway downstream processing |
| 基金项目:国家自然科学基金项目（21476042）；国家民委重点实验室开放课题（KF2015006） |
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| 中文摘要: |
| 1,3-丙二醇（1,3-PD）是一种重要的化工原料，广泛应用于医药、化工、食品及化妆品等行业,同时1,3-PD 是合成聚对苯二甲酸丙二酯（PTT）的重要单体，市场需求量逐年增多。基于生态友好型、生产安全和可持续发展的要求，利用微生物转化可再生资源来生产1,3-PD受到了人们的广泛重视。综述了微生物发酵法生产1,3-PD的菌株、代谢途径、发酵和下游分离工艺及其新进展，并对工业生产中利用生物技术生产1,3-PD的未来前景和挑战进行了探讨。 |
| 英文摘要: |
| 1,3-Propanediol (1,3-PD) is an important raw material which is widely used in pharmaceutical, chemical, food and cosmetic industries. As a promising monomer for the synthesis of poly(trimethylene terephthalate) (PTT), its market demand is increasing linearly. Based on the demand of safe and eco-friendly production process and sustainable development, microbial conversion of renewable resources into 1,3-PD has been paid more and more attention. In this paper, we will discuss 1,3-PD producers with relation to their metabolism and fermentation technologies, as well as the downstream processing of biologically produced 1,3-PD. The prospects and challenges for the industrial production of bio-based 1,3-PD are also presented. |
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