| Common pathogen distribution and drug resistance of blood culture samples in the First Affiliated Hospital of China Medical University from 2009 to 2012 was investigated using BACTEC9240 full automatic blood culture of American BD Company and its accessory cultural bottles. All the isolated pathogens were carried out bacterial identification and drug sensitivity tests adopting French Biomerieux Vitel 2 and/or BD Pheonenix 100 and the data were analyzed their bacterial spectrum and drug resistance by WHONET 5.6 software. The results showed that 3 295 pathogens were isolated from 28 179 blood culture samples with the positive rate at 11.69%, among them 1 649 strains (5005%) were Gram positive cocci, 1 331 strains (40.39%) were Gram negative bacilli, and 112 strains [KG(-0.1mm](3.4%) were fungi. The highest isolation rate of bacteria was coagulase negative staphylococcus (34.26%), followed by 〖WTBX〗E. coli 〖WTBZ〗(10.44%), 〖WTBX〗Klebsiella pneumoniae〖WTBZ〗 (8.22%), 〖WTBX〗Acinetobacter baumannii〖WTBZ〗 (5.13%), 〖WTBX〗Staphylococcus aureus 〖WTBZ〗(48%), 〖WTBX〗Pseudomonas aeruginosa 〖WTBZ〗(3.28%), and 〖WTBX〗Enterococcus faecalis 〖WTBZ〗(3.28%). The drug susceptibility of staphylococci to linezolid, vancomycin, and teicoplanin were highly sensitive. Methicillin resistant isolates accounted for 4620% among 〖WTBX〗S. aureus. 〖WTBZ〗Methicillin resistant isolates accounted for 85.74% among coagulase negative staphylococcus. The susceptibility of gram negative bacilli (except 〖WTBX〗A. baumannii〖WTBZ〗) to carbapenems was relatively high. The resistance rates of Gram negative bacilli to cephalosporins and quinolones were relatively high. The detection rates of extra spectrum β lactamase producing 〖WTBX〗E. coli 〖WTBZ〗and 〖WTBX〗K. pneumoniae 〖WTBZ〗accounted for 57.56% and 36.9% respectively.[KG)] Pathogens that caused bacteremia are of various species, many of them has fairly high rate of drug resistance, and clinician should pay attention to the pathogenic changes and drug resistance to modify antibiotic treatment timely. |
